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Laparoscopic Radical Resection versus Routine Surgery for Colorectal Cancer
Computational and Mathematical Methods in Medicine ( IF 2.809 ) Pub Date : 2022-9-30 , DOI: 10.1155/2022/4899555
Yan Chen 1, 2 , Dong Xi 1, 2 , Qiutao Zhang 1, 2
Affiliation  

For patients with colorectal cancer, minimally invasive surgical methods, particularly laparoscopic methods, are now the preferred course of therapy. This research is performed to investigate the effects of laparoscopic radical resection on patients with colorectal cancer. A total of 100 colorectal cancer patients treated in our hospital from January 2017 to January 2019 were enrolled. The subjects were divided into observation () and control () groups and treated with laparoscopic surgery and laparotomy, respectively. As well as postoperative complications and survival rates, the levels of inflammatory substances, stress response, immunological function, and perioperative markers were compared between the two groups. There was no significant difference in the postoperative exhaust time between the two groups (). Compared with the control group, the observation group showed longer operation time, faster recovery of intestinal function, shorter hospital stay, and less intraoperative bleeding amount (). The serum contents of hs-CRP, TNF-α, IL-6, norepinephrine, adrenaline, and cortisol at 1 d, 3 d, and 5 d after surgery were significantly higher than before in both groups (). Moreover, the serum contents of hs-CRP, TNF-α, IL-6, norepinephrine, adrenaline, and cortisol in the observation group were significantly lower than that in the control group (). At 10 days following surgery, immune index levels had dramatically increased in both groups, with noticeably higher immune index levels in the observation group than in the control group (). There were no appreciable differences in the two groups’ 2-year survival rates (), but the complication rate was much greater in the control group (). To sum up, after laparoscopic surgery, patients had fewer complications, shorter hospital stay, lower inflammatory factor expression, less stress response, better immune function, less trauma, faster recovery, and improved quality of life.

中文翻译:

腹腔镜根治性切除与结直肠癌的常规手术

对于结直肠癌患者,微创手术方法,尤其是腹腔镜方法,现在是首选的治疗方案。本研究旨在探讨腹腔镜根治性切除术对结直肠癌患者的影响。2017年1月至2019年1月在我院收治的大肠癌患者共100例入组。将受试者分为观察组()和控制 ()组,分别接受腹腔镜手术和剖腹手术治疗。比较两组患者术后并发症、生存率、炎症物质水平、应激反应、免疫功能、围手术期标志物水平。两组术后排气时间无显着差异()。与对照组相比,观察组手术时间更长,肠功能恢复更快,住院时间更短,术中出血量更少。)。两组术后1 d、3 d、5 d血清hs-CRP、TNF- α、IL-6、去甲肾上腺素、肾上腺素、皮质醇含量均显着高于术前。)。此外,观察组血清中hs-CRP、TNF- α、IL-6、去甲肾上腺素、肾上腺素、皮质醇含量均显着低于对照组。)。术后10天,两组免疫指标均显着升高,观察组免疫指标明显高于对照组。)。两组的 2 年生存率没有明显差异(),但对照组的并发症发生率要高得多()。综上所述,腹腔镜手术后患者并发症少、住院时间短、炎症因子表达低、应激反应少、免疫功能好、创伤小、恢复快、生活质量提高。
更新日期:2022-09-30
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