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Ring contraction in synthesis of functionalized carbocycles
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2022-09-29 , DOI: 10.1039/d1cs01080h
Chunngai Hui 1, 2 , Luke Craggs 3 , Andrey P Antonchick 1, 2, 3
Affiliation  

Carbocycles are a key and widely present structural motif in organic compounds. The construction of structurally intriguing carbocycles, such as highly-strained fused rings, spirocycles or highly-functionalized carbocycles with congested stereocenters, remains challenging in organic chemistry. Cyclopropanes, cyclobutanes and cyclopentanes within such carbocycles can be synthesized through ring contraction. These ring contractions involve re-arrangement of and/or small molecule extrusion from a parental ring, which is either a carbocycle or a heterocycle of larger size. This review provides an overview of synthetic methods for ring contractions to form cyclopropanes, cyclobutanes and cyclopentanes en route to structurally intriguing carbocycles.

中文翻译:

功能化碳环合成中的环收缩

碳环是有机化合物中一个关键且广泛存在的结构基序。结构上有趣的碳环的构建,例如高应变稠环、螺环或具有拥挤立体中心的高功能化碳环,在有机化学中仍然具有挑战性。此类碳环中的环丙烷、环丁烷和环戊烷可通过环收缩合成。这些环收缩涉及母环的重排和/或小分子挤出,母环是碳环或更大尺寸的杂环。本综述概述了环收缩形成环丙烷、环丁烷和环戊烷的合成方法,以形成结构上有趣的碳环。
更新日期:2022-09-29
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