Mild cognitive impairment (MCI) is a heterogeneous condition with high individual variabilities in clinical outcomes driven by patient demographics, genetics, brain structure features, blood biomarkers, and comorbidities. Multi-modality data-driven approaches have been used to discover MCI subtypes; however, disease comorbidities have not been included as a modality though multiple diseases including hypertension are well-known risk factors for Alzheimer's disease (AD). The aim of this study was to examine MCI heterogeneity in the context of AD-related comorbidities along with other AD-relevant features and biomarkers.

中文翻译：

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阿尔茨海默病轻度认知障碍的合并症驱动多模态亚型分析

轻度认知障碍 (MCI) 是一种异质性疾病，在患者人口统计学、遗传学、大脑结构特征、血液生物标志物和合并症的驱动下，临床结果存在高度个体差异。多模态数据驱动方法已被用于发现 MCI 亚型；然而，尽管包括高血压在内的多种疾病是阿尔茨海默病 (AD) 的众所周知的危险因素，但疾病合并症并未被列为一种模式。本研究的目的是在 AD 相关合并症以及其他 AD 相关特征和生物标志物的背景下检查 MCI 异质性。