Purpose. To probe the property of serum uric acid in evaluating the activity of patients with thyroid-associated ophthalmopathy. Methods. A total of 443 patients with TAO admitted to our hospital from March 2016 to February 2021 were selected for the observation group. Simultaneously, 443 healthy subjects were selected for the control group. The observation group was divided into the active group () and the inactive group () according to the clinical activity score (CAS). Besides, the patients were divided into mild group (), moderate severe group () and extremely severe group () based on the severity of TAO. Serum uric acid, free triiodothyronine (FT3), free thyroid hormone (FT4), thyrotropin stimulating hormone (TSH) and glycosylated hemoglobin (HbA1c) levels were detected and analyzed in each group. Results. Serum UA, FT3, FT4, TSH and HbA1c in the active group were significantly enhanced than those in the other two groups (), and there was no significant difference between the inactive group and the control group (). In different disease severity groups, the serum UA level of patients in the active group was significantly promoted than that in the inactive group and control group () and was decreased successively in extremely severe group, moderate severe group and mild group, with statistical significance (). Pearson’s analysis showed that UA was positively correlated with FT3, FT4, and HbA1c (; ; ), while was reversely correlated with TSH level (). There was no correlation between UA and FT3, FT4, and HbA1c levels in the inactive group. UA detection showed the average sensitivity and specificity of TAO activity were 94.3% and 85.2%, respectively. There was no significant correlation between the severity of disease and serum UA in inactive patients (). There was a positive correlation between the severity of disease and serum UA in active patients (). Conclusion. UA may be used as a laboratory indicator for quantitative clinical diagnosis of thyroid-associated ophthalmopathy (TAO) and as a parameter for the presence of TAO activity.

中文翻译：

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甲状腺相关性眼病患者血清尿酸检测及相关性分析

目的。探讨血清尿酸在评估甲状腺相关眼病患者活动性中的作用。方法。选取2016年3月至2021年2月我院收治的TAO患者443例为观察组。同时选取443名健康受试者作为对照组。观察组分为活动组（)和非活动组 ()根据临床活动评分 (CAS)。此外，将患者分为轻度组（),中重度组 ()和极重度组 ()基于 TAO 的严重程度。检测分析各组血清尿酸、游离三碘甲状腺原氨酸（FT3）、游离甲状腺激素（FT4）、促甲状腺激素（TSH）和糖化血红蛋白（HbA1c）水平。结果。活性组血清UA、FT3、FT4、TSH、HbA1c明显高于其他两组（），非活动组与对照组无显着差异（）。在不同疾病严重程度组中，活动组患者血清UA水平显着高于非活动组和对照组（)，极重度组、中度重度组和轻度组依次降低，具有统计学意义(）。Pearson 的分析表明，UA 与 FT3、FT4 和 HbA1c 呈正相关（; ; ),而与 TSH 水平呈负相关 (）。在非活动组中，UA 与 FT3、FT4 和 HbA1c 水平之间没有相关性。UA检测显示TAO活性的平均敏感性和特异性分别为94.3%和85.2%。非活动患者的疾病严重程度与血清 UA 无显着相关性（）。活动患者的疾病严重程度与血清 UA 呈正相关（）。 结论。UA 可用作甲状腺相关眼病 (TAO) 定量临床诊断的实验室指标和 TAO 活性存在的参数。