A personal account is given of the research and development that has led to the first large-scale application of a Crabtree/Pfaltz-type iridium catalyst for industrial enantioselective hydrogenation. The journey from first screening results to established process shows the importance of industrial and academic collaborations in a modern chemical development environment. An evaluation of the vast sustainability gains in the preparation of the key Inpyrfluxam intermediate RATM is included.

中文翻译：

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关于合作在可持续催化过程开发中的重要性：Inpyrfluxam 案例

个人介绍了导致 Crabtree/Pfaltz 型铱催化剂首次大规模应用于工业对映选择性氢化的研究和开发。从最初的筛选结果到确定过程的旅程表明了工业和学术合作在现代化学开发环境中的重要性。包括对制备关键 Inpyrfluxam 中间体 RATM 的巨大可持续性收益的评估。