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Efficacy of Ginkgo biloba Extract Combined with Hormones in the Treatment of Sudden Deafness and Its Effect on the Reactivity of Peripheral Blood T Cell Subsets
Computational and Mathematical Methods in Medicine ( IF 2.809 ) Pub Date : 2022-9-26 , DOI: 10.1155/2022/2903808
Zhenhua Zhu 1 , Qi Wu 1 , Ge Hu 1 , Xianwen Wang 1 , Wei Chang 1 , Ji Bin 1 , Weili Yang 1
Affiliation  

This work was aimed at exploring the efficacy of Ginkgo biloba extract combined with hormones in the treatment of sudden deafness and the influence on the reactivity of peripheral blood T cell subsets (PBTCSs). In this work, 64 patients with sudden deafness who were treated in The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from August 2019 to August 2022 were selected as the research objects. The patients were randomly divided into a hormone group (treatment with prednisone acetate, ) and a combination group (treatment with Ginkgo-Damole combined with prednisone acetate, ). After the two groups of patients were treated in different ways, their efficacy, symptom improvement, changes in blood rheology, and PBTCSs were compared. The total effective rates (TERs) of the hormone group and the combination group were 76.32% and 95.73%, respectively (). The fibrinogen contents of the patients in the combination group were obviously lower than those in the hormone group after 5 d, 7 d, and 10 d of treatment (). The high blood viscosity (HBV) values of patients in the combination group at 5 d, 7 d, and 10 d after treatment were greatly lower than those in the hormone group (). The low blood viscosity (LBV) values after 3 d, 7 d, and 10 d of treatment in the combined group were much lower in contrast to those in the hormone group (). The CD3+, CD4+, and CD4+/CD8+ in peripheral blood in the combination group were sharply higher while the CD8+ in the combined group was lower in contrast to the hormone group (). There was no visible difference in the incidence of adverse reactions between the two groups of patients after treatment (). In conclusion, the combined application of Ginkgo biloba extract and hormones could effectively improve the abnormal hemorheological indexes of patients with sudden deafness and effectively relieve the imbalance of PBTCSs, which was safe.

中文翻译:

银杏叶提取物联合激素治疗突发性耳聋的疗效及其对外周血T细胞亚群反应性的影响

本工作旨在探讨银杏叶提取物联合激素治疗突发性耳聋的疗效及对外周血T细胞亚群(PBTCSs)反应性的影响。本次研究选取2019年8月至2022年8月在湖南中医药大学第一附属医院收治的64例突发性耳聋患者作为研究对象。患者被随机分为激素组(醋酸泼尼松治疗、和联合组(银杏达莫联合醋酸泼尼松治疗,)。两组患者经过不同方式治疗后,比较其疗效、症状改善情况、血液流变学变化、PBTCSs。激素组和联合组的总有效率(TER)分别为76.32%和95.73%()。治疗5 d、7 d、10 d后联合组患者纤维蛋白原含量明显低于激素组()。联合组患者治疗后5、7、10天的高血液粘度(HBV)值均显着低于激素组()。联合组治疗3天、7天和10天后的低血液粘度(LBV)值远低于激素组()。与激素组相比,联合组外周血CD3+、CD4+、CD4+/CD8+急剧升高,而CD8+则降低()。两组患者治疗后不良反应发生率无明显差异()。综上所述,银杏叶提取物与激素联合应用可有效改善突发性耳聋患者异常的血液流变学指标,有效缓解PBTCS失衡,且安全。
更新日期:2022-09-26
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