Childhood Guillain–Barré syndrome (GBS) is a rare neurological disease. Early diagnosis followed by precise treatment can reduce mortality. In this study, we collected two transcriptome data between GBS and controls from the publicly available databases (GEO dataset). We identified two distinct down-regulated genes (PTGDS and AR) in GBS by transcriptome analysis (n = 20). Based on the two distinct down-regulated genes in the GBS group, a two-gene diagnostic signature was developed. Moreover, gene expression analysis for the two-gene was performed on a patient with GBS before and after Supportive Care. RT–PCR results show that the expression of PTGDS increased after the patient was given supportive care. Therefore, PTGDS might be considered as a potential target for therapeutic target in GBS.

儿童格林-巴利综合征 (GBS) 是一种罕见的神经系统疾病。早期诊断和精准治疗可以降低死亡率。在这项研究中，我们从公开可用的数据库（GEO 数据集）中收集了 GBS 和对照之间的两个转录组数据。我们通过转录组分析鉴定了 GBS 中两个不同的下调基因（PTGDS 和 AR）。n= 20)。基于 GBS 组中两个不同的下调基因，开发了一种双基因诊断特征。此外，在支持治疗前后对一名 GBS 患者进行了双基因的基因表达分析。RT-PCR结果显示，患者接受支持治疗后PTGDS表达增加。因此，PTGDS 可能被认为是 GBS 治疗靶点的潜在靶点。