The aging process is manifested by a multitude of inter-linked biological processes. These processes contribute to genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, de-regulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The mammalian ortholog of the yeast silent information regulator (Sir2) SIRT1 is a NAD+-dependent class III histone deacetylase and has been recognized to be involved in many of the forementioned processes. Furthermore, the physiological activity of several Sirtuin family members has been connected to the regulation of life span of lower organisms (Caenorhabditis elegans and Drosophila melanogaster) as well as mammals.

中文翻译：

---

尿源性肾祖细胞中年龄累积的 DNA 损伤与 SIRT1-AKT-GSK3ß 轴之间的串扰

衰老过程表现为大量相互关联的生物过程。这些过程导致基因组不稳定、端粒损耗、表观遗传改变、蛋白质稳态丧失、营养感应失调、线粒体功能障碍、细胞衰老、干细胞耗竭和细胞间通讯改变。酵母沉默信息调节因子 (Sir2) SIRT1 的哺乳动物直系同源物是一种 NAD+ 依赖性 III 类组蛋白脱乙酰酶，已被认为参与许多上述过程。此外，一些 Sirtuin 家族成员的生理活动与低等生物（秀丽隐杆线虫和黑腹果蝇）以及哺乳动物的寿命调节有关。