Biomarkers defining biological age are typically laborious or expensive to assess. Instead, in the current study, we identified parameters based on standard laboratory blood tests across metabolic, cardiovascular, inflammatory, and kidney functioning that had been assessed in the Berlin Aging Study (BASE) (n = 384) and Berlin Aging Study II (BASE-II) (n = 1517). We calculated biological age using those 12 parameters that individually predicted mortality hazards over 26 years in BASE. In BASE, older biological age was associated with more physician-observed morbidity and higher mortality hazards, over and above the effects of chronological age, sex, and education. Similarly, in BASE-II, biological age was associated with physician-observed morbidity and subjective health, over and above the effects of chronological age, sex, and education as well as alternative biomarkers including telomere length, DNA methylation age, skin age, and subjective age but not PhenoAge. We discuss the importance of biological age as one indicator of aging.

定义生物年龄的生物标志物的评估通常很费力或昂贵。相反，在当前的研究中，我们根据柏林老龄化研究 (BASE) ( n  = 384) 和柏林老龄化研究 II (BASE ) 中评估的代谢、心血管、炎症和肾功能的标准实验室血液测试确定了参数。-II) ( n  = 1517)。我们使用 BASE 中分别预测 26 岁以上死亡风险的 12 个参数计算了生物年龄。在 BASE 中，除实际年龄、性别和教育程度的影响外，较大的生物年龄与医生观察到的更多发病率和更高的死亡风险相关。同样，在 BASE-II 中，生物年龄与医生观察到的发病率和主观健康状况相关，而不仅仅是实际年龄、性别和教育程度以及替代生物标志物（包括端粒长度、DNA 甲基化年龄、皮肤年龄和皮肤年龄）的影响。主观年龄但不是 PhenoAge。我们讨论生物年龄作为衰老指标之一的重要性。