Down syndrome (DS) is associated with immune dysregulation and a high risk of early onset Alzheimer's disease (AD). Complement is a key part of innate immunity and driver of pathological inflammation, including neuroinflammation in AD. Complement dysregulation has been reported in DS; however, the pattern of dysregulation and its relationship to AD risk is unclear.

中文翻译：

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唐氏综合症中的补体失调和阿尔茨海默病

唐氏综合症 (DS) 与免疫失调和早发性阿尔茨海默病 (AD) 的高风险有关。补体是先天免疫的关键部分和病理性炎症的驱动因素，包括 AD 中的神经炎症。补体失调在 DS 中已有报道；然而，失调的模式及其与 AD 风险的关系尚不清楚。