Mosquito-borne pathogens constitute a major health problem worldwide. The extermination of the mosquito remains a significant issue in public health. Chemical insecticides have been used to control mosquitoes for decades. However, resistance has become a limiting factor for their control. The anthranilic diamide insecticides possess excellent insecticidal activities against Lepidoptera and its resistant strains by draining internal calcium stores on activating insect ryanodine receptors. However, the reports on the effect on mosquitoes are scarce and hence a series of novel anthranilic diamides comprising acyl thiourea substructure were synthesized and their insecticidal activities against three vector mosquito larvae namely, Culex quinquefasciatus, Aedes aegypti and Anopheles stephensi were evaluated as per WHO protocol. Also investigated the morphological observations of treated larvae.

中文翻译：

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含酰基硫脲亚结构的新型邻氨基苯甲酸二酰胺的设计、合成、表征及杀虫筛选

蚊子传播的病原体构成了世界范围内的一个主要健康问题。消灭蚊子仍然是公共卫生中的一个重要问题。几十年来，化学杀虫剂一直被用来控制蚊子。然而，阻力已成为他们控制的限制因素。邻氨基苯甲酸二酰胺杀虫剂通过消耗激活昆虫兰尼碱受体的内部钙储存，对鳞翅目及其抗性菌株具有优异的杀虫活性。然而，关于对蚊子影响的报道很少，因此合成了一系列包含酰基硫脲亚结构的新型邻氨基苯甲酸二酰胺及其对三种媒介蚊子幼虫的杀虫活性，即Culex quinquefasciatus，Aedes aegypti和按照 WHO 方案对斯氏按蚊进行了评估。还研究了处理过的幼虫的形态观察。