当前位置: X-MOL 学术Environ. Toxicol. Pharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Trace elements repartition in body fluids, hair and organs in an autopsied population evaluated by ICP-MS high resolution
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2022-09-23 , DOI: 10.1016/j.etap.2022.103978
Marie Bellouard 1 , Geoffroy Lorin de la GrandMaison 2 , Julien Cappy 2 , Lamiae Grimaldi 3 , Albine Lontsi-Djeagou 3 , Jean-Claude Alvarez 1
Affiliation  

Exposure to metals and trace elements (TE) is universal and can cause toxicity in case of excessive exposure. We evaluated the concentrations and tissue distribution of 39 TE using high-resolution ICP-MS after total mineralization by microwave in twenty autopsied French subjects. We found a globally homogeneous distribution of TE in the body, with some accumulations in agents, involved in respiratory pathologies and classified as carcinogens, in the lungs. The liver, an organ of metabolism, appeared to concentrate Co, Fe, La, Mn, Mo, Pb and Zn. Fe seemed to accumulate in the spleen, the organ of hematopoiesis. The kidney showed high concentrations of some TE, which can cause nephrotoxicity. The use of microwave mineralization and high-resolution ICP-MS allowed accurate quantification and a very high sensitivity, without spectral interferences. The results obtained in this study could be used to support the interpretation of post-mortem metal concentrations in tissues.



中文翻译:

通过 ICP-MS 高分辨率评估尸检人群的体液、头发和器官中的微量元素重新分配

接触金属和微量元素 (TE) 是普遍现象,如果过度接触会导致毒性。我们使用高分辨率 ICP-MS 在 20 名法国尸检对象中通过微波完全矿化后评估了 39 TE 的浓度和组织分布。我们发现 TE 在体内的全球均匀分布,在肺部有一些物质积累,涉及呼吸道疾病并被归类为致癌物。肝脏是一种新陈代谢器官,似乎富含 Co、Fe、La、Mn、Mo、Pb 和 Zn。Fe似乎积聚在脾脏,造血器官。肾脏显示出高浓度的一些 TE,可引起肾毒性。使用微波矿化和高分辨率 ICP-MS 可以实现准确的定量和非常高的灵敏度,而不会产生光谱干扰。

更新日期:2022-09-25
down
wechat
bug