Clonal expansion of DNMT3A-mutant hematopoietic stem cells is a risk factor for myeloid malignancies and other morbidities. A new study uses multi-modal single-cell genomics to characterize the myeloid differentiation bias of DNMT3A-mutated clones, and finds preferential hypomethylation of binding motifs for key transcriptional regulators.

中文翻译：

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DNMT3A 突变造血干细胞的克隆扩增是骨髓恶性肿瘤和其他病态的危险因素。一项新研究使用多模式单细胞基因组学来表征 DNMT3A 突变克隆的骨髓分化偏倚，并发现关键转录调节因子结合基序的优先低甲基化。