Evodiamine is a major alkaloid component found in the fruit of Evodia rutaecarpa. It shows the anti-proliferative potential against a wide range of cancers by suppressing cell growth, invasion, and metastasis and inducing apoptosis both in vitro and in vivo. Evodiamine shows its anticancer potential by modulating aberrant signaling pathways. Additionally, the review focuses on several therapeutic implications of evodiamine, such as epigenetic modification, cancer stem cells, and epithelial to mesenchymal transition. Moreover, combinatory drug therapeutics along with evodiamine enhances the anticancer efficacy of chemotherapeutic drugs in various cancers by overcoming the chemo resistance and radio resistance shown by cancer cells. It has been widely used in preclinical trials in animal models, exhibiting very negligible side effects against normal cells and effective against cancer cells. The pharmacokinetic and pharmacodynamics-based collaborations of evodiamine are also included. Due to its poor bioavailability, synthetic analogs of evodiamine and its nano capsule have been formulated to enhance its bioavailability and reduce toxicity. In addition, this review summarizes the ongoing research on the mechanisms behind the antitumor potential of evodiamine, which proposes an exciting future for such interests in cancer biology.

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中文翻译：

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吴茱萸碱作为一种抗癌剂：对其在多种癌症中的治疗应用、药代动力学、毒性和代谢的全面综述

吴茱萸碱是吴茱萸果实中的主要生物碱成分。它通过抑制细胞生长、侵袭和转移以及在体外和体内诱导细胞凋亡，显示出针对多种癌症的抗增殖潜力。 Evodiamine 通过调节异常信号通路显示其抗癌潜力。此外，该综述重点关注吴茱萸碱的几种治疗意义，例如表观遗传修饰、癌症干细胞和上皮间充质转化。此外，组合药物疗法与吴茱萸碱一起通过克服癌细胞表现出的化学抗性和放射抗性来增强化学治疗药物在各种癌症中的抗癌功效。它已广泛用于动物模型的临床前试验，对正常细胞的副作用几乎可以忽略不计，对癌细胞有效。吴茱萸碱的药代动力学和药效学协作也包括在内。由于其生物利用度差，吴茱萸碱的合成类似物及其纳米胶囊已被配制以提高其生物利用度并降低毒性。此外，这篇综述总结了正在进行的关于吴茱萸碱抗肿瘤潜力背后机制的研究，这为癌症生物学的此类兴趣提出了令人兴奋的未来。

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