In the present study, effect of exposure of bisphenol A (BPA) and combined exposure of BPA + HSD has been investigated on the glucose homeostasis and associated renal complications in Drosophila. Exposure of 1.0 mM BPA alone induced type 2 diabetes like condition (T2D) in adult male D. melanogaster via oxidative stress. Elevated TGF-β signaling was evident by increased expression of baboon (babo) in BPA exposed organism that stimulated the modulation of extracellular matrix (ECM) component collagen IV resulting in the fibrosis of the Malpighian tubules (MTs). Combined exposure of BPA + HSD (high sucrose diet) resulted in the increased magnitude of T2D and MTs dysfunction parameters. Taken together, the study illustrates that BPA has diabetogenic potential in exposed Drosophila that caused adverse effects on their MTs and combined exposure with BPA and HSD could aggravate the renal tubular dysfunction. The study further suggests the use of Drosophila model to study the environmental chemicals induced diabetes mediated renal dysfunction.

在本研究中，研究了双酚 A (BPA) 暴露和 BPA + HSD 联合暴露对果蝇葡萄糖稳态和相关肾脏并发症的影响。单独暴露 1.0 mM BPA通过氧化应激在成年男性黑腹果蝇中诱导 2 型糖尿病样病症 (T2D) 。暴露于 BPA 的生物体中狒狒 (babo) 的表达增加，刺激了细胞外基质 (ECM) 成分胶原蛋白 IV 的调节，导致马氏小管 (MT) 纤维化，TGF-β 信号升高明显。BPA + HSD（高蔗糖饮食）的联合暴露导致 T2D 和 MTs 功能障碍参数的幅度增加。综上所述，该研究表明，BPA 在暴露的果蝇中具有致糖尿病的潜力，会对它们的 MT 造成不利影响，同时暴露于 BPA 和 HSD 会加重肾小管功能障碍。该研究进一步建议使用果蝇模型来研究环境化学物质诱发糖尿病介导的肾功能障碍。