The effect of preaxial polydactyly of the foot on health-related quality of life (HR-QoL) has not been investigated in current literature. To improve counseling, we investigated HR-QoL in this patient group. A patient-control study was performed with children with preaxial polydactyly (n = 20), adults with preaxial polydactyly (n = 15), children with postaxial polydactyly (n = 15) and healthy controls (n = 62). The primary outcome was the difference in the foot-specific quality of life (FS-QoL) between children with preaxial polydactyly and adults with preaxial polydactyly, children with postaxial polydactyly and controls, using the Oxford Ankle and Foot Questionnaire (OxAFQ-c) and five foot-specific visual analogue scales (VAS). The secondary outcome was the difference in general HR-QoL, using the Pediatric Quality of Life Inventory (PedsQL). Outcomes were compared with the Mann–Whitney-U test. Comparison between children with preaxial polydactyly and healthy controls and postaxial polydactyly showed worse outcomes in all OxAFQ-c domains. The foot-specific VAS score was significantly worse in children with preaxial polydactyly compared to postaxial polydactyly and controls. Only the PedsQL physical domain showed a lower outcome in children with preaxial polydactyly than in postaxial polydactyly and controls. Children and adults with preaxial polydactyly scored the same in all domains. The OxAFQ-c and the PedsQL physical domain showed significantly worse outcomes in children with preaxial polydactyly compared with healthy controls and postaxial polydactyly. However, large variation was observed, suggesting large differences between patients. In children and adults, the foot and scar appearance seems to be the biggest problem, while diminished foot function seems less of an issue.

目前的文献尚未研究足部轴前多指畸形对健康相关生活质量(HR-QoL) 的影响。为了改进咨询，我们调查了该患者组的 HR-QoL。对轴前多指畸形儿童 ( n  = 20)、轴前多指畸形成人 ( n  = 15)、轴后多指畸形儿童 ( n  = 15) 和健康对照组 ( n  = 62)进行了患者对照研究。主要结果是足部特定生活质量的差异(FS-QoL) 在轴前多指畸形儿童和轴前多指畸形成人、轴后多指畸形儿童和对照组之间，使用牛津踝关节和足部问卷 (OxAFQ-c) 和五只脚特定视觉模拟量表 (VAS)。次要结果是一般 HR-QoL 的差异，使用儿科生活质量库存（PedsQL）。将结果与 Mann-Whitney-U 检验进行比较。轴前多指畸形儿童与健康对照儿童和轴后多指畸形儿童之间的比较显示所有 OxAFQ-c 域的结果更差。与轴后多指畸形和对照组相比，轴前多指畸形儿童的足部特异性 VAS 评分明显更差。只有 PedsQL 物理域显示轴前多指畸形儿童的结果低于轴后多指畸形和对照组。患有轴前多指畸形的儿童和成人在所有领域的得分相同。与健康对照和轴后多指畸形相比，OxAFQ-c 和 PedsQL 物理域显示患有轴前多指畸形的儿童的结果明显更差。然而，观察到很大的差异，表明患者之间存在很大差异。在儿童和成人中，