The long non-coding RNA HOTAIR is exclusively expressed in gluteofemoral subcutaneous adipose tissue (GSAT) and is functionally required for GSAT adipocyte differentiation. A genetic variation analysis showed that the minor allele of rs1443512 is associated with reduced HOTAIR expression and decreased adipose tissue mass in the leg and gynoid regions.

中文翻译：

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HOTAIR 是脂肪组织特定区域发育的基础

长的非编码 RNA HOTAIR 仅在臀股皮下脂肪组织 (GSAT) 中表达，并且是 GSAT 脂肪细胞分化所必需的功能。遗传变异分析表明，rs1443512 的次要等位基因与 HOTAIR 表达减少和腿部和女性区域的脂肪组织质量减少有关。