A novel deep eutectic solvent (DES) with tributyl phosphate (TBP) as hydrogen bond acceptor and D,L-menthol (M) as hydrogen bond donor (HBD) was synthesized for the first time. M, a natural perfume, was selected as the HBD of the promising DES to tailor the extraction capacity and greenify the extraction solvent. The designed TBP–M (molar ratio 1 : 2)-based DES was applied in the simultaneous liquid–liquid microextraction (LLME) of a group of parabens (PBs) and their metabolite (p-hydroxybenzoic acid, PHBA) with wide polarity range in surface water samples. The developed LLME was combined with high-performance liquid chromatography and showed low detection limits (0.5–0.9 μg L⁻¹) and good linearity (R² ≥ 0.9983), precisions (RSDs ≤ 7.6%) and recoveries (86.0% to 110%) under the optimum conditions. The presented procedure has the features of simplicity, inexpensiveness, effectiveness and reliability, and the novel DES has great potential in the highly effective and simultaneous extraction for compounds with different polarities such as PBs and PHBA in complex real water samples.

中文翻译：

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新型基于磷酸三丁酯的疏水性深共熔溶剂：在地表水样品中对羟基苯甲酸酯及其代谢物的同时液-液微萃取中的应用

首次合成了以磷酸三丁酯（TBP）为氢键受体，D，L-薄荷醇（M）为氢键供体（HBD）的新型深共熔溶剂（DES）。M 是一种天然香料，被选为有前途的 DES 的 HBD，以调整提取能力并绿化提取溶剂。设计的基于 TBP-M（摩尔比 1 : 2）的 DES 应用于极性范围较宽的一组对羟基苯甲酸酯（PBs）及其代谢物（对羟基苯甲酸，PHBA）的同时液液微萃取（LLME）在地表水样品中。开发的 LLME 与高效液相色谱相结合，具有低检测限 (0.5–0.9 μg L ^-1 ) 和良好的线性 ( R ²≥ 0.9983)、精密度 (RSD ≤ 7.6%) 和最佳条件下的回收率 (86.0% 至 110%)。所提出的程序具有简单、廉价、有效和可靠的特点，新型DES在高效同时提取复杂真实水样中的PBs和PHBA等不同极性化合物方面具有巨大潜力。