The effectiveness of current antimicrobial methods for addressing for food-borne Gram-positive pathogens has dropped with the emergence of resistant strains. Consequently, new methods for addressing Gram-positive strains have to be developed continuously. This includes establishing novel targets for antimicrobial discovery efforts. Eukaryotic choline kinases have been highly developed as drug targets for the treatment of cancer, rheumatoid arthritis, malaria and many other conditions and diseases. Recently, choline kinase (ChoK) has been proposed as a drug target for Gram-positive species generally. The aim of this work was to discover novel, natural sources of inhibitors for bacterial ChoK from tea extracts. We report the first natural bacterial ChoK inhibitor with antimicrobial activity against Streptococcus pneumoniae: quercetin.

中文翻译：

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槲皮素是肺炎链球菌胆碱激酶的新型抑制剂

随着耐药菌株的出现，目前用于解决食源性革兰氏阳性病原体的抗菌方法的有效性已经下降。因此，必须不断开发处理革兰氏阳性菌株的新方法。这包括为抗菌素发现工作建立新的目标。真核生物胆碱激酶已被高度开发为用于治疗癌症、类风湿性关节炎、疟疾和许多其他病症和疾病的药物靶标。最近，胆碱激酶（ChoK）已被提议作为革兰氏阳性菌的药物靶标。这项工作的目的是从茶提取物中发现新的、天然的细菌 ChoK 抑制剂来源。我们报告了第一个对肺炎链球菌具有抗菌活性的天然细菌 ChoK 抑制剂: 槲皮素。