Nanoemulsion (NE), a lipid-based drug delivery system, plays an important role in delivering drugs and enhancing bioavailability. They are mainly taken up by the reticuloendothelial system, because of which their bioavailability is diminished, leading to poor therapeutic activity. It is important to protect this delivery system using a coating agent. Thus, we have coated o/w type NE using polyethylene glycol (PEG). The novelty in our study is use of dicarboxylic acid-linked PEG. Furthermore, the spontaneous emulsification method was used in preparation and peg coating, not mentioned previously. After the preparation of NE, various characterization and stability studies were carried out. We have also optimized the ratios for NE and PEG NE by using various concentrations of Smix, PEG, and water. Also, the same has also been plotted in a pseudoternary-phase diagram. As a conclusion, the PEGylation of NE was carried out successfully and may also be used for linking with other ligands because of the presence of COOH group.

中文翻译：

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使用自发乳化法对纳米乳液进行聚乙二醇化

纳米乳剂（NE）是一种基于脂质的药物递送系统，在递送药物和提高生物利用度方面起着重要作用。它们主要被网状内皮系统吸收，因此它们的生物利用度降低，导致治疗活性差。使用涂层剂保护该输送系统非常重要。因此，我们使用聚乙二醇 (PEG) 包覆了 o/w 型 NE。我们研究的新颖之处在于使用二羧酸连接的 PEG。此外，自发乳化法用于制备和PEG涂层，这是以前没有提到的。NE制备完成后，进行了各种表征和稳定性研究。我们还通过使用各种浓度的 Smix、PEG 和水优化了 NE 和 PEG NE 的比例。还，同样的情况也被绘制在伪三元相图中。作为结论，NE 的聚乙二醇化成功进行，并且由于存在 COOH 基团，也可用于与其他配体连接。