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Adaptive immune responses in patients requiring revision after total knee arthroplasty
Journal of Orthopaedic Research ( IF 2.8 ) Pub Date : 2022-09-19 , DOI: 10.1002/jor.25445 Daniel Jenkins 1 , Swati Phalke 1 , Richard Bell 2, 3 , Samantha Lessard 4 , Sanjay Gupta 1 , Mark Youssef 5 , Kathleen Tam 5 , Allina Nocon 5 , Juan Rivera-Correa 1 , Timothy Wright 6 , Thomas Sculco 5 , Miguel Otero 4, 7 , Alessandra B Pernis 1, 3, 8, 9 , Peter Sculco 5
Journal of Orthopaedic Research ( IF 2.8 ) Pub Date : 2022-09-19 , DOI: 10.1002/jor.25445 Daniel Jenkins 1 , Swati Phalke 1 , Richard Bell 2, 3 , Samantha Lessard 4 , Sanjay Gupta 1 , Mark Youssef 5 , Kathleen Tam 5 , Allina Nocon 5 , Juan Rivera-Correa 1 , Timothy Wright 6 , Thomas Sculco 5 , Miguel Otero 4, 7 , Alessandra B Pernis 1, 3, 8, 9 , Peter Sculco 5
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Dissatisfaction occurs in nearly 20% of patients after total knee arthroplasty (TKA); however, there remains only limited understanding of the biologic mechanisms that may contribute to suboptimal postoperative outcomes requiring revision surgery. Expansion of effector T and B cells, could promote an abnormal healing response via local or peripheral immune system mechanisms and contribute to inferior outcomes necessitating revision TKA. In this pilot study, we hypothesized that patients suffering from complications of arthrofibrosis or instability may exhibit differences in adaptive immune function.
中文翻译:
全膝关节置换术后需要翻修的患者的适应性免疫反应
全膝关节置换术(TKA)后近20%的患者出现不满意;然而,对可能导致需要翻修手术的次优术后结果的生物学机制的了解仍然有限。效应 T 细胞和 B 细胞的扩增可通过局部或外周免疫系统机制促进异常愈合反应,并导致需要翻修 TKA 的不良结果。在这项初步研究中,我们假设患有关节纤维化并发症或不稳定的患者可能表现出适应性免疫功能的差异。
更新日期:2022-09-19
中文翻译:
全膝关节置换术后需要翻修的患者的适应性免疫反应
全膝关节置换术(TKA)后近20%的患者出现不满意;然而,对可能导致需要翻修手术的次优术后结果的生物学机制的了解仍然有限。效应 T 细胞和 B 细胞的扩增可通过局部或外周免疫系统机制促进异常愈合反应,并导致需要翻修 TKA 的不良结果。在这项初步研究中,我们假设患有关节纤维化并发症或不稳定的患者可能表现出适应性免疫功能的差异。