Subchondral bone plays an important role in the pathogenesis of radiographic osteoarthritis (OA). However, the bony changes that occur in hand OA (HOA) are much less understood. This study aimed to describe the association between radiographic HOA and high-resolution peripheral quantitative computed tomography (HRpQCT) measures of the hand and radius in a population-based sample. A total of 201 participants (mean age 72, 46% female) from the Tasmanian Older Adult Cohort (TASOAC) study underwent HRpQCT assessment of the 2nd distal and proximal interphalangeal (DIP, PIP), 1st carpometacarpal (CMC) joint, and distal radius. Radiographic HOA was assessed at the 2nd DIP, PIP joints, and the 1st CMC joint using the OARSI atlas. Proximal osteophyte and joint space narrowing (JSN) scores were consistently more strongly associated with HRpQCT measures compared to the distal site with positive associations for indices of bone size (total and trabecular bone area and cortical perimeter but inconsistent for cortical area) and negative associations for volumetric bone mineral density (vBMD). There was a decrease in trabecular number and bone volume fraction with increasing osteophyte and JSN score as well as an increase in trabecular separation and inhomogeneity. Osteophyte and JSN scores in the hand were not associated with HRpQCT measures at the distal radius. This hypothesis generating data suggests that bone size and trabecular disorganization increase with both osteophyte formation and JSN (proximal more than distal), while local vBMD decreases. This process appears to be primarily at the site of pathology rather than nearby unaffected bone.

中文翻译：

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基于人群的样本中放射照相手部骨关节炎与骨微结构之间的关联

软骨下骨在影像学骨关节炎 (OA) 的发病机制中起重要作用。然而，手部 OA (HOA) 中发生的骨骼变化却鲜为人知。本研究旨在描述射线照相 HOA 与基于人群的样本中手部和桡骨的高分辨率外周定量计算机断层扫描 (HRpQCT) 测量值之间的关联。来自塔斯马尼亚老年队列 (TASOAC) 研究的总共 201 名参与者（平均年龄 72 岁，46% 为女性）接受了第二远端和近端指间关节（DIP、PIP）、第一腕掌 (CMC) 关节和远端桡骨关节的 HRpQCT 评估. 使用 OARSI 图集在第 2 个 DIP、PIP 关节和第 1 个 CMC 关节处评估放射学 HOA。与远端部位相比，近端骨赘和关节间隙狭窄 (JSN) 评分与 HRpQCT 测量值的相关性更强，与骨尺寸指数（总骨小梁面积和皮质周长，但皮质面积不一致）呈正相关，而皮质面积呈负相关体积骨矿物质密度 (vBMD)。随着骨赘和 JSN 评分的增加，小梁数量和骨体积分数减少，小梁分离和不均匀性增加。手中的骨赘和 JSN 评分与桡骨远端的 HRpQCT 测量值无关。这一假设生成的数据表明，骨大小和小梁结构紊乱随着骨赘形成和 JSN（近端多于远端）而增加，而局部 vBMD 减少。