Due to the complexity and particularity of cancer cell microenvironments, redox responsive drug delivery systems (DDSs) for cancer therapy have been extensively explored. Compared with widely reported cancer treatment systems based on disulfide bonds, diselenide bonds have better redox properties and greater anticancer efficiency. In this review, the significance and application of diselenide bonds in DDSs are summarized, and the stimulation sensitivity of diselenide bonds is comprehensively reported. The potential and prospects for the application of diselenide bonds in next-generation anticancer drug treatment systems are extensively discussed.

中文翻译：

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深入了解用于癌症治疗的药物递送系统中的刺激响应二硒键

由于癌细胞微环境的复杂性和特殊性，已经广泛探索了用于癌症治疗的氧化还原响应药物递送系统（DDS）。与广泛报道的基于二硫键的癌症治疗系统相比，二硒键具有更好的氧化还原性能和更高的抗癌效率。本文综述了二硒键在DDSs中的意义和应用，全面报道了二硒键的刺激敏感性。广泛讨论了二硒键在下一代抗癌药物治疗系统中的应用潜力和前景。