Xylo-oligosaccharides (XOS) has a bidirectional regulatory effect, and can be fermented by gut microbiota. This study aims to investigate how XOS alleviates Folium Sennae extracts induced diarrhea in mice. KM mice are given different concentration XOS for 3 weeks, and then Folium Sennae (Senna alexandrina Mill) extracts solutions (0.8 g mL⁻¹) are given to establish diarrhea model. The results show that doses of XOS at 0.25 mg g⁻¹ BW day⁻¹ and higher could alleviate diarrhea symptoms by decreasing the disease activity indexes, down-regulating pro-inflammatory factors, up-regulating anti-inflammatory factor, and suppressing the intestinal permeability in colon tissues. XOS also regulates the composition of gut microbiota via increasing the abundance Prevotellaceae, Ruminococcus, and Bifidobacterium. The results suggest that the dietary supplementation XOS could be a more effective choice to prevent and alleviate diarrhea.

中文翻译：

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口服低聚木糖 (XOS) 通过改善肠道屏障和调节肠道微生物群来改善小鼠的腹泻症状

低聚木糖 (XOS) 具有双向调节作用，可被肠道菌群发酵。本研究旨在探讨 XOS 如何减轻番泻叶提取物引起的小鼠腹泻。KM小鼠给予不同浓度XOS 3周，然后给予番泻叶( Senna alexandrina Mill )提取液(0.8 g mL ^-1 )建立腹泻模型。结果表明，XOS 的剂量为 0.25 mg g ⁻¹ BW day ⁻¹及更高水平可通过降低疾病活动指标、下调促炎因子、上调抗炎因子、抑制结肠组织的肠道通透性来减轻腹泻症状。XOS 还通过增加Prevotellaceae、Ruminococcus和Bifidobacterium的丰度来调节肠道微生物群的组成。结果表明，膳食补充剂 XOS 可能是预防和减轻腹泻的更有效选择。