Background

Acute bone loss after fracture is associated with various effects on the complete recovery process and a risk of secondary fractures among patients. Studies have reported similarities in pathophysiological mechanisms involved in acute bone loss after fractures and osteoporosis. However, given the silence nature of bone loss and bone metabolism complexities, the actual underlying pathophysiological mechanisms have yet to be fully elucidated.

Aim of review

To elaborate the latest findings in basic research with a focus on acute bone loss after fracture. To briefly highlight potential therapeutic targets and current representative drugs. To arouse researchers' attention and discussion on acute bone loss after fracture.

Key scientific concepts of review

Bone loss after fracture is associated with immobilization, mechanical unloading, blood supply damage, sympathetic nerve regulation, and crosstalk between musculoskeletals among other factors. Current treatment strategies rely on regulation of osteoblasts and osteoclasts, therefore, there is a need to elucidate on the underlying mechanisms of acute bone loss after fractures to inform the development of efficacious and safe drugs. In addition, attention should be paid towards ensuring long-term skeletal health.

中文翻译：

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骨折后急性骨丢失的病理生理机制

背景

骨折后急性骨质流失与患者完全恢复过程的各种影响以及继发骨折的风险有关。研究报告了骨折和骨质疏松后急性骨质流失的病理生理机制的相似性。然而，鉴于骨丢失的沉默性质和骨代谢的复杂性，实际的潜在病理生理机制尚未完全阐明。

审查目的

阐述基础研究的最新发现，重点关注骨折后急性骨质流失。简要介绍潜在的治疗靶点和当前的代表性药物。旨在引起研究者对骨折后急性骨丢失的关注和讨论。

审查的关键科学概念

骨折后的骨质流失与固定、机械卸载、血液供应损伤、交感神经调节以及肌肉骨骼之间的串扰等因素有关。目前的治疗策略依赖于成骨细胞和破骨细胞的调节，因此，需要阐明骨折后急性骨质流失的潜在机制，为开发有效且安全的药物提供信息。此外，应注意确保长期骨骼健康。