In this study, we report a simple approach to preparing platelet-like strontium vanadate (SrV) supported on a graphitic carbon nitride (SrV/GCN) nanocomposite using a two-step synthesis process. An SrV/GCN nanocomposite modified glassy carbon electrode (GCE) was explored for the highly selective simultaneous electrochemical detection of the antibiotic drugs acetaminophen (ACAMP) and levofloxacin (LEV). The structure, morphology, and crystalline features of the SrV/GCN nanocomposite were characterized using different microscopy and spectroscopic techniques. The incorporation of SrV nanostructures onto GCN can remarkably improve the active surface area, electrical conductivity, and electrochemical performance. As a result, the constructed SrV/GCN/GCE sensor exhibits a remarkably high sensitivity of 15.79 and 14.27 μA μM⁻¹ cm⁻², a wide linear range of 0.019–1100 μM, and a low detection limit (LOD) of 0.026 and 0.028 μM for ACAMP and LEV, respectively. Moreover, the sensor showed exceptional selectivity and operational stability for the simultaneous detection of ACAMP and LEV without any interference effects. Finally, the practical use of the proposed sensor was validated in spiked real samples, such as human blood serum, human urine, commercial antibiotic tablets, and river water samples, offering promising opportunities for practical clinical analysis.

中文翻译：

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钒酸锶负载的石墨氮化碳纳米复合材料用于同时伏安法测定复杂生物样品中的对乙酰氨基酚和左氧氟沙星

在这项研究中，我们报告了一种使用两步合成工艺制备支撑在石墨氮化碳 (SrV/GCN) 纳米复合材料上的片状钒酸锶 (SrV) 的简单方法。探索了一种 SrV/GCN 纳米复合改性玻碳电极 (GCE) 用于对抗生素药物对乙酰氨基酚 (ACAMP) 和左氧氟沙星 (LEV) 的高选择性同时电化学检测。使用不同的显微镜和光谱技术对 SrV/GCN 纳米复合材料的结构、形态和晶体特征进行了表征。将 SrV 纳米结构结合到 GCN 上可以显着提高活性表面积、电导率和电化学性能。因此，构建的 SrV/GCN/GCE 传感器表现出非常高的灵敏度，分别为 15.79 和 14.27 μA μM ^-1cm ^-2，0.019-1100 μM 的宽线性范围，ACAMP 和 LEV 的低检测限 (LOD) 分别为 0.026 和 0.028 μM。此外，该传感器在同时检测 ACAMP 和 LEV 时表现出出色的选择性和操作稳定性，而没有任何干扰效应。最后，该传感器的实际应用在加标的真实样品中得到了验证，例如人血清、人尿、商业抗生素片剂和河水样品，为实际临床分析提供了有希望的机会。