CD11b+CD43hiLy6Clo splenocyte-derived macrophages exacerbate liver fibrosis via spleen–liver axis,Hepatology

当前位置： X-MOL 学术 › Hepatology › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

CD11b+CD43hiLy6Clo splenocyte-derived macrophages exacerbate liver fibrosis via spleen–liver axis
Hepatology ( IF 13.5 ) Pub Date : 2022-09-13 , DOI: 10.1002/hep.32782
Shaoying Zhang _{1,

2,

3} , Dan Wan _{1,

2,

3} , Mengchen Zhu _{1,

2,

3} , Guihu Wang _{1,

2,

3} , Xurui Zhang _{1,

2,

3} , Na Huang _{1,

2} , Jian Zhang _{1,

2} , Chongyu Zhang _{1,

2,

3} , Qi Shang _{1,

2,

3} , Chen Zhang _{1,

2,

3} , Xi Liu _{1,

2,

3} , Fanfan Liang _{1,

2,

3} , Chunyan Zhang ₁ , Guangyao Kong _{1,

2} , Jing Geng _{1,

3} , Libo Yao ₁ , Shemin Lu _{1,

3,

4} , Yongyan Chen _{5,

6} , Zongfang Li _{1,

2,

3,

4}

Affiliation

Monocyte-derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression. The spleen serves as an extra monocyte reservoir in inflammatory conditions; however, the precise mechanisms of involvement of the spleen in the pathogenesis of liver fibrosis remain unclear.

中文翻译：