Anti-melanogenic agents: The design, synthesis, docking and inhibitory assays toward tyrosinase (TYR) from Agaricus bisporus (AbTYR) were performed for a series of (4-(4-hydroxyphenyl)piperazin-1-yl)arylmethanone derivatives. The most promising compound 10 displayed antioxidant activity combined with no cytotoxicity in MTT tests and exerted anti-melanogenic effects on B16F10 cells.

中文翻译：

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基于 4-(4-羟基苯基) 哌嗪的靶向酪氨酸酶的化合物的设计、合成和体外评价

抗黑素剂：对一系列 (4-(4-hydroxyphenyl)piperazin-1-yl)arylmethanone 衍生物进行了来自双孢蘑菇(AbTYR) 的酪氨酸酶 (TYR) 的设计、合成、对接和抑制测定。最有前途的化合物 10 在 MTT 测试中显示出抗氧化活性且无细胞毒性，并且对 B16F10 细胞具有抗黑色素生成作用。