Recent monkeypox (MPX) outbreaks are major ones in non-endemic countries. The present study analyzed molecular phylogenetics, divergence, epidemiology, the geographical distribution, entropy diversity of genome, mutational landscape, and evolution of the monkeypox virus (MPXV) genome and the current MPXV is entitled “hMPXV1.” We used different in-silico and statistical methods to study our objectives. The developed phylogram from molecular phylogenetics describes the origin and evolution of hMPXV1 of A, A.1, A.1.1, A.2, and B.1 lineages. The microevolution of B.1 lineage shows its evolution from May to August 2022. B.1 lineage is further adapting and showing more mutation and sub-lineages. The scatter plot of all lineages shows the clustering pattern of lineages and the divergence. We also developed two statistical models of confirmed cases and a diagram of the age-related pattern of infected cases to illustrate the epidemiology of the MPX outbreaks. The entropy diversity and mutational landscape of the hMPXV1 genome were analyzed in nucleotide and codon contexts. Our study has shown the in-depth evolution pattern of different lineages of the hMPXV1. We found B.1 lineage is associated with the current outbreaks. The mutational landscape informs about the slow mutation of the virus. Finally, the study might assists the new therapeutic development considering all the above points and would help the researcher to set up their future research directions.

最近猴痘 (MPX) 疫情主要发生在非流行国家。本研究分析了猴痘病毒（MPXV）基因组的分子系统发育、分歧、流行病学、地理分布、基因组熵多样性、突变景观和进化，目前的 MPXV 被命名为“hMPXV1”。我们使用不同的计算机和统计方法来研究我们的目标。分子系统发生学开发的系统图描述了 A、A.1、A.1.1、A.2 和 B.1 谱系的 hMPXV1 的起源和进化。B.1谱系的微观进化显示了其从2022年5月到2022年8月的进化。B.1谱系正在进一步适应并显示出更多的突变和亚谱系。所有谱系的散点图显示了谱系的聚类模式和分歧。我们还开发了两种确诊病例统计模型和感染病例年龄相关模式图，以说明 MPX 暴发的流行病学。在核苷酸和密码子背景下分析了 hMPXV1 基因组的熵多样性和突变景观。我们的研究展示了 hMPXV1 不同谱系的深入进化模式。我们发现 B.1 谱系与当前的疫情爆发有关。突变景观表明病毒的缓慢突变。最后，考虑到上述所有要点，该研究可能有助于新疗法的开发，并有助于研究人员确定未来的研究方向。