Atractylenolide I (AI) is a natural sesquiterpene lactone isolated from Atractylodes macrocephala Koidz, known as Baizhu in traditional Chinese medicine. AI has been found to ameliorate cancer cachexia in clinic cancer patients and in tumour-bearing mice. Here, we checked the influence of AI on biogenesis of IL-6 and extracellular vesicles (EVs) in cancer cachexia mice and then focused on studying mechanisms of AI in inhibiting the production of tumour-derived EVs, which contribute to the ameliorating effects of AI on cancer cachexia.

中文翻译：

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Atractylenolide I 通过抑制 IL-6 和肿瘤来源的细胞外囊泡的生物发生来改善癌症恶病质

Atractylenolide I (AI) 是从白术中分离得到的天然倍半萜内酯，中药称为白术。已发现 AI 可以改善临床癌症患者和荷瘤小鼠的癌症恶病质。在这里，我们检查了 AI 对癌症恶病质小鼠 IL-6 和细胞外囊泡 (EVs) 生物发生的影响，然后重点研究了 AI 抑制肿瘤衍生 EVs 产生的机制，这有助于 AI 的改善作用关于癌症恶病质。