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Programmable Assembly of Multivalent DNA-Protein Superstructures for Tumor Imaging and Targeted Therapy
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2022-09-09 , DOI: 10.1002/anie.202211505
Zhen Xu 1 , Tianhui Shi 1 , Fengye Mo 1 , Wenqian Yu 1 , Yu Shen 1 , Qunying Jiang 1 , Fuan Wang 1 , Xiaoqing Liu 1
Affiliation  

Programmable multivalent DNA nanomaterials are designed through the biomimetic assembly of DNA with Food and Drug Administration-approved protamine, providing biocompatible and stable drug carriers with high avidity in a simpler method. This practical approach achieves sensitive tumor imaging and targeted cancer therapy, and offers new clinical translation opportunities.

中文翻译:

用于肿瘤成像和靶向治疗的多价 DNA-蛋白质超结构的可编程组装

可编程多价 DNA 纳米材料是通过 DNA 与食品和药物管理局批准的鱼精蛋白的仿生组装设计的,以更简单的方法提供具有高亲和力的生物相容性和稳定的药物载体。这种实用的方法实现了敏感的肿瘤成像和靶向癌症治疗,并提供了新的临床转化机会。
更新日期:2022-09-09
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