For its various important functions in cells, phosphatase and tensin homolog-induced kinase 1 (PINK1) has drawn considerable attention for the role it plays in early-onset Parkinson's disease. In recent years, emerging evidence has supported the hypothesis that PINK1 plays a part in regulating many physiological and pathophysiological processes in cancer cells, including cytoplasmic homeostasis, cell survival, and cell death. According to the findings of these studies, PINK1 can function as a tumor promoter or suppressor, showing a duality that is dependent on the context. In this study we review the mechanistic characters relating to PINK1 based on available published data from peer-reviewed articles, The Cancer Genome Atlas data mining, and cell-based assays. This mini review focuses on some of the interplays between PINK1 and the context and recent developments in the field, including its growing involvement in mitophagy and its nonmitophagy organelles-related function. This review aims to help readers better grasp how PINK1 is functioning in cell physiological and pathophysiological processes, especially in cancer biology.

中文翻译：

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PINK1 在癌症生物学中新出现的多方面作用

由于其在细胞中的各种重要功能，磷酸酶和张力蛋白同系物诱导激酶 1 (PINK1) 在早发性帕金森病中发挥的作用引起了相当大的关注。近年来，新出现的证据支持 PINK1 在调节癌细胞的许多生理和病理生理过程中发挥作用的假设，包括细胞质稳态、细胞存活和细胞死亡。根据这些研究的结果，PINK1 可以作为肿瘤启动子或抑制子发挥作用，显示出依赖于环境的二元性。在这项研究中，我们根据同行评审文章、癌症基因组图谱数据挖掘和基于细胞的测定中可用的已发表数据，回顾了与 PINK1 相关的机制特征。这篇迷你评论重点介绍了 PINK1 与该领域的背景和近期发展之间的一些相互作用，包括它越来越多地参与线粒体自噬及其非线粒体自噬细胞器相关功能。本综述旨在帮助读者更好地了解 PINK1 在细胞生理和病理生理过程中的作用，尤其是在癌症生物学中。