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Dehydrozingerone Alleviates Hyperalgesia, Oxidative Stress and Inflammatory Factors in Complete Freund’s Adjuvant-Induced Arthritic Rats
Drug Design, Development and Therapy ( IF 4.8 ) Pub Date : 2022-09-08 , DOI: 10.2147/dddt.s374827 Chunhong Liu 1, 2 , Yetian Li 3 , Chaoling Wen 4 , Zheng Yan 2 , Opeyemi Joshua Olatunji 5 , Zongsheng Yin 3
Drug Design, Development and Therapy ( IF 4.8 ) Pub Date : 2022-09-08 , DOI: 10.2147/dddt.s374827 Chunhong Liu 1, 2 , Yetian Li 3 , Chaoling Wen 4 , Zheng Yan 2 , Opeyemi Joshua Olatunji 5 , Zongsheng Yin 3
Affiliation
Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease with severe inflammatory responses. Dehydrozingerone (DHZ) is a potent bioactive compound found in the rhizomes of Zingiber officinale, and it has been reported as an excellent anti-inflammatory and antioxidant agent. This study evaluated the anti-arthritic effects of DHZ in complete Freund’s adjuvant (CFA)-induced arthritis.
Methods: CFA administered rats were intragastrically treated with DHZ (100 mg/kg) for 28 days, and arthritis severity was assessed via body weight, arthritic score, paw edema and hyperalgesia. Serum inflammation biomarkers, oxidative stress markers, inflammatory cytokines and liver function enzymes were evaluated.
Results: The results indicated that DHZ significantly ameliorated arthritis severity as shown by reduced arthritic score, thymus and spleen indexes, paw circumference, paw withdrawal threshold and latency as well as increased body weight gain. Furthermore, DHZ treatment persuasively reduced serum levels of alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), rheumatoid factor (RF), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-1β and 6 (IL-1β and IL-6), malondialdehyde (MDA), vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). In addition, DHZ observably increased serum superoxide dismutase (SOD) and glutathione (GSH) levels in treated rats.
Conclusion: These findings suggest that DHZ possesses anti-RA effect properties via modulating the inflammatory responses and oxidative stress.
Keywords: dehydrozingerone, anti-arthritis, complete Freund’s adjuvant, inflammation, oxidative stress, rheumatoid arthritis
中文翻译：
Dehydrozingerone 减轻完全弗氏佐剂诱导的关节炎大鼠的痛觉过敏、氧化应激和炎症因子
目的：类风湿性关节炎（RA）是一种具有严重炎症反应的慢性自身免疫性疾病。Dehydrozingerone (DHZ) 是一种在姜根茎中发现的有效生物活性化合物，据报道它是一种极好的抗炎和抗氧化剂。本研究评估了 DHZ 在完全弗氏佐剂 (CFA) 诱导的关节炎中的抗关节炎作用。
方法：给予 CFA 的大鼠用 DHZ（100 mg/kg）灌胃 28 天，通过体重、关节炎评分、爪水肿和痛觉过敏评估关节炎严重程度。评估了血清炎症生物标志物、氧化应激标志物、炎性细胞因子和肝功能酶。
结果：结果表明，DHZ 显着改善关节炎严重程度，表现为关节炎评分、胸腺和脾脏指数、爪周长、爪缩回阈值和潜伏期以及体重增加增加。此外，DHZ 治疗令人信服地降低了碱性磷酸酶 (ALP)、天冬氨酸转氨酶 (AST)、丙氨酸转氨酶 (ALT)、类风湿因子 (RF)、C 反应蛋白 (CRP)、肿瘤坏死因子α (TNF-α) 的血清水平、白细胞介素1β和6（IL-1β和IL-6）、丙二醛（MDA）、血管内皮生长因子（VEGF）和转化生长因子β（TGF-β）。此外，DHZ 显着增加治疗大鼠的血清超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH) 水平。
结论：这些发现表明，DHZ 通过调节炎症反应和氧化应激具有抗 RA 作用特性。
关键词：脱氢姜黄酮，抗关节炎，完全弗氏佐剂，炎症，氧化应激，类风湿性关节炎
更新日期：2022-09-08
Methods: CFA administered rats were intragastrically treated with DHZ (100 mg/kg) for 28 days, and arthritis severity was assessed via body weight, arthritic score, paw edema and hyperalgesia. Serum inflammation biomarkers, oxidative stress markers, inflammatory cytokines and liver function enzymes were evaluated.
Results: The results indicated that DHZ significantly ameliorated arthritis severity as shown by reduced arthritic score, thymus and spleen indexes, paw circumference, paw withdrawal threshold and latency as well as increased body weight gain. Furthermore, DHZ treatment persuasively reduced serum levels of alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), rheumatoid factor (RF), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-1β and 6 (IL-1β and IL-6), malondialdehyde (MDA), vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). In addition, DHZ observably increased serum superoxide dismutase (SOD) and glutathione (GSH) levels in treated rats.
Conclusion: These findings suggest that DHZ possesses anti-RA effect properties via modulating the inflammatory responses and oxidative stress.
Keywords: dehydrozingerone, anti-arthritis, complete Freund’s adjuvant, inflammation, oxidative stress, rheumatoid arthritis
中文翻译：
Dehydrozingerone 减轻完全弗氏佐剂诱导的关节炎大鼠的痛觉过敏、氧化应激和炎症因子
目的：类风湿性关节炎（RA）是一种具有严重炎症反应的慢性自身免疫性疾病。Dehydrozingerone (DHZ) 是一种在姜根茎中发现的有效生物活性化合物，据报道它是一种极好的抗炎和抗氧化剂。本研究评估了 DHZ 在完全弗氏佐剂 (CFA) 诱导的关节炎中的抗关节炎作用。
方法：给予 CFA 的大鼠用 DHZ（100 mg/kg）灌胃 28 天，通过体重、关节炎评分、爪水肿和痛觉过敏评估关节炎严重程度。评估了血清炎症生物标志物、氧化应激标志物、炎性细胞因子和肝功能酶。
结果：结果表明，DHZ 显着改善关节炎严重程度，表现为关节炎评分、胸腺和脾脏指数、爪周长、爪缩回阈值和潜伏期以及体重增加增加。此外，DHZ 治疗令人信服地降低了碱性磷酸酶 (ALP)、天冬氨酸转氨酶 (AST)、丙氨酸转氨酶 (ALT)、类风湿因子 (RF)、C 反应蛋白 (CRP)、肿瘤坏死因子α (TNF-α) 的血清水平、白细胞介素1β和6（IL-1β和IL-6）、丙二醛（MDA）、血管内皮生长因子（VEGF）和转化生长因子β（TGF-β）。此外，DHZ 显着增加治疗大鼠的血清超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH) 水平。
结论：这些发现表明，DHZ 通过调节炎症反应和氧化应激具有抗 RA 作用特性。
关键词：脱氢姜黄酮，抗关节炎，完全弗氏佐剂，炎症，氧化应激，类风湿性关节炎
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