Zebrafish (Danio rerio) is an increasingly popular vertebrate model used for assessing the toxicity of endocrine-disrupting chemicals (EDCs) on living beings. The zebrafish features high genetic homology to mammals, because of its rapid embryonic development, optical transparency of phenotypic screening embryos, high throughput genetic and chemical screening which make them a powerful toxicological model. This systematic review aimed to assess the recent literature on the use of zebrafish model in EDCs toxicity studies. We capture the data on the types of EDCs used, zebrafish life stages associated with the toxicity, and its effects on the alterations in neuroendocrine factors and cardiac hypoxia in zebrafish. A total of 17 articles published between 2010 and 2020 were curated. The information gathered highlighted the association of EDCs with cardiological outcomes and neurobehavioral effects and distorted expression of genes. The genes that were highlighted in the paper include bdnf, ntrk2a, grin2cb, VTG-1, HIF-1α, tnnt2, ntrk1, and pax6b. The effect of EDCs on cardiac hypoxia and neurodevelopmental and behavioral factors of zebrafish were described in all the papers chosen for this review. The involvement of EDCs in altered regulation of gene expression can be studied further to identify the potential EDC compounds on its toxicological and endocrine disruption function at the molecular level.

斑马鱼（斑马鱼) 是一种越来越流行的脊椎动物模型，用于评估内分泌干扰物 (EDC) 对生物的毒性。斑马鱼与哺乳动物具有高度的遗传同源性，因为其胚胎发育迅速、表型筛选胚胎的光学透明性、高通量遗传和化学筛选使其成为强大的毒理学模型。本系统评价旨在评估最近关于在 EDC 毒性研究中使用斑马鱼模型的文献。我们捕获了有关使用的 EDC 类型、与毒性相关的斑马鱼生命阶段及其对斑马鱼神经内分泌因子和心脏缺氧改变的影响的数据。2010 年至 2020 年间共发表了 17 篇文章。收集到的信息强调了 EDC 与心脏病学结果和神经行为影响以及基因扭曲表达的关联。论文中强调的基因包括bdnf、ntrk2a、grin2cb、VTG-1、HIF-1α、tnnt2、ntrk1 和 pax6b。本综述选择的所有论文都描述了 EDCs 对斑马鱼心脏缺氧和神经发育和行为因素的影响。可以进一步研究 EDC 参与改变基因表达的调节，以在分子水平上确定潜在的 EDC 化合物对其毒理学和内分泌干扰功能的影响。