Background: Aging-related cognitive decline is an early symptom of Alzheimer’s disease and other dementias, and on its own can have substantial consequences on an individual’s ability to perform important everyday functions. Despite increasing interest in the potential roles of extracellular microRNAs (miRNAs) in central nervous system (CNS) pathologies, there has been little research on extracellular miRNAs in early stages of cognitive decline. We leverage the longitudinal Normative Aging Study (NAS) cohort to investigate associations between plasma miRNAs and cognitive function among cognitively normal men.

中文翻译：

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老年男性前瞻性队列中的细胞外 microRNA 和认知功能：退伍军人事务规范老龄化研究

背景：与衰老相关的认知能力下降是阿尔茨海默病和其他痴呆症的早期症状，其本身可能对个人执行重要日常功能的能力产生重大影响。尽管人们对细胞外 microRNA (miRNA) 在中枢神经系统 (CNS) 病理学中的潜在作用越来越感兴趣，但对细胞外 miRNA 在认知衰退早期阶段的研究却很少。我们利用纵向规范衰老研究 (NAS) 队列来研究认知正常男性的血浆 miRNA 与认知功能之间的关联。