Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis,Hepatology

当前位置： X-MOL 学术 › Hepatology › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology ( IF 13.5 ) Pub Date : 2022-09-04 , DOI: 10.1002/hep.32776
Jana Knorr _{1,

2} , Benedikt Kaufmann _{3,

4} , Maria Eugenia Inzaugarat ₅ , Theresa Maria Holtmann ₁ , Lukas Geisler ₁ , Jana Hundertmark ₁ , Marlene Sophia Kohlhepp ₁ , Laela M Boosheri ₃ , Daisy R Chilin-Fuentes ₆ , Amanda Birmingham ₆ , Kathleen M Fisch ₆ , Joel D Schilling ₇ , Sven H Loosen ₈ , Christian Trautwein ₅ , Christoph Roderburg ₈ , Münevver Demir ₁ , Frank Tacke ₁ , Hal M Hoffman ₃ , Ariel E Feldstein ₃ , Alexander Wree _{1,

3}

Affiliation

Department of Hepatology and Gastroenterology , Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum and Charité Campus Mitte , Berlin , Germany.
Department of Biology , Humboldt-Universität zu Berlin , Berlin , Germany.
Department of Pediatrics , University of California, San Diego, Rady Children's Hospital San Diego California , San Diego , California , USA.
Department of Surgery , TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich , Munich , Germany.
Department of Internal Medicine III , RWTH University Hospital Aachen , Aachen , Germany.
Center for Computational Biology & Bioinformatics , University of California, San Diego , La Jolla , California , USA.
Division of Cardiovascular Diseases, Department of Internal Medicine , Washington University School of Medicine , St. Louis , Missouri , USA.
Clinic for Gastroenterology, Hepatology and Infectious Diseases , Medical Faculty of Heinrich Heine University Düsseldorf , University Hospital Düsseldorf , Düsseldorf , Germany.

Nucleotide-binding oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL-18 in hepatic stellate cells (HSCs), and its impact on liver fibrosis.

中文翻译：

Interleukin-18信号促进小鼠肝纤维化中肝星状细胞的激活

核苷酸结合寡聚化结构域样受体家族包含热蛋白结构域 3 (NLRP3) 炎性体激活已被证明会导致肝纤维化。机制和下游信号传导仍未完全了解。在这里，我们研究了 IL-18 在肝星状细胞 (HSC) 中的作用及其对肝纤维化的影响。

更新日期：2022-09-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>