To electrophysiologically determine the impact of moderate to severe chronic hypoxia (H) resulting from a wide array of CHD (HCHD) conditions on the integrity of brainstem function.

Applying brainstem auditory-evoked response methodology, 30 chronically afflicted HCHD patients, who already had undergone heart surgery, were compared to 28 healthy control children (1–15 yo) matched by age, gender and socioeconomic condition. Blood oxygen saturation was clinically determined and again immediately before brainstem auditory-evoked response testing.

Among HCHD children, auditory wave latencies (I, III and V) were significantly longer (medians: I, 2.02 ms; III, 4.12 ms, and; V, 6.30 ms) compared to control (medians: I, 1.67ms; III, 3.72 ms, and; V, 5.65 ms), as well as interpeak intervals (HCHD medians: I-V, 4.25 ms, and; III-V, 2.25ms; control medians: I-V, 3.90 ms and, III-V, 1.80 ms) without significant differences in wave amplitudes between groups. A statistically significant and inverse correlation between average blood oxygen saturation of each group (control, 94%; HCHD, 78%) and their respective wave latencies and interpeak intervals was found.

As determined by brainstem auditory-evoked responses, young HCHD patients manifestly show severely altered neuronal conductivity in the auditory pathway strongly correlated with their hypoxic condition. These observations are strongly supported by different brainstem neurological and image studies showing that alterations, either in microstructure or function, result from the condition of chronic hypoxia in CHD. The non-altered wave amplitudes are indicative of relatively well-preserved neuronal relay nuclei.

从电生理学角度确定多种冠心病 (HCHD) 引起的中度至重度慢性缺氧 (H) 对脑干功能完整性的影响。

应用脑干听觉诱发反应方法，将 30 名已接受心脏手术的慢性 HCHD 患者与 28 名年龄、性别和社会经济状况相匹配的健康对照儿童（1-15 岁）进行比较。在脑干听觉诱发反应测试之前再次临床测定血氧饱和度。

在 HCHD 儿童中，与对照组（中位数：I，1.67ms；III， 3.72 ms，和；V，5.65 ms），以及峰间间隔（HCHD 中位数：IV，4.25 ms，和；III-V，2.25 ms；对照中位数：IV，3.90 ms 和 III-V，1.80 ms）组间波幅无显着差异。发现每组的平均血氧饱和度（对照组，94％；HCHD，78％）与其各自的波潜伏期和峰间间隔之间存在统计学上显着的负相关。

根据脑干听觉诱发反应确定，年轻的 HCHD 患者明显表现出听觉通路中神经元传导性的严重改变，这与他们的缺氧状况密切相关。这些观察结果得到了不同脑干神经学和图像研究的有力支持，这些研究表明，微结构或功能的改变是由先心病慢性缺氧引起的。未改变的波幅表明神经元中继核保存相对完好。