Unexpected weight loss (UWL) in patients consulting in primary care presents dilemmas for management because of the broad differential diagnoses associated with UWL. Research on the risks of serious disease among patients with UWL to date has largely taken place in secondary care, limiting generalizability to primary care patients. In this study, we use a large matched cohort study to estimate the risks of 12 serious diseases among patients presenting to primary care with UWL where this was recorded, stratified by age and sex, in order to inform a rational clinical approach to patients presenting with UWL.

中文翻译：

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意外体重减轻患者的严重疾病风险：超过 70 000 个初级保健报告的匹配队列

由于与 UWL 相关的广泛鉴别诊断，初级保健咨询患者的意外体重减轻 (UWL) 给管理带来了困境。迄今为止，关于 UWL 患者严重疾病风险的研究主要在二级保健中进行，限制了对初级保健患者的普遍性。在这项研究中，我们使用一项大型匹配队列研究来估计因 UWL 而就诊于初级保健机构的患者患 12 种严重疾病的风险，并按年龄和性别对其进行了分层记录，以便为就诊于患有 UWL 的患者提供合理的临床方法UWL。