MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a ‘body’ and two ‘wings’. Intermolecular interactions are mainly distributed in the ‘body’ which is relatively stable, while two ‘wings’ are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family.

中文翻译：

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人 MG53 同源二聚体的冷冻电镜结构

MG53 是一种三方基序 (TRIM) 家族 E3 连接酶，具有重要的生物学功能。在这里，我们展示了人类 MG53 的冷冻电镜结构，表明 MG53 是由一个“身体”和两个“翅膀”组成的同源二聚体。分子间相互作用主要分布在相对稳定的“身体”中，而两个“翅膀”则更具动态性。MG53 的整体结构与 TRIM20 和 TRIM25 的结构不同，说明了该蛋白质家族的广泛结构多样性。