The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co-expressed with the MTTP gene that encodes for microsomal triglyceride transfer protein, key to the lipidation of apolipoprotein B, the core protein of VLDL. Using human and murine transcriptomic data sets, we identified small leucine-rich protein 1 (SMLR1), encoding for small leucine-rich protein 1, a protein of unknown function that is exclusively expressed in liver and small intestine.

中文翻译：

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肝脏 SMLR1 缺失会导致肝脂肪变性，并可因肝脏 VLDL 分泌减少而预防动脉粥样硬化

VLDL 在肝脏中的组装和分泌是影响肝脏和血浆脂质的一种途径，目前尚不完全清楚。我们着手通过鉴定与编码微粒体甘油三酯转移蛋白的MTTP基因共表达的基因来鉴定 VLDL 生物合成途径中的参与者，该蛋白是载脂蛋白 B（VLDL 核心蛋白）脂化的关键。使用人类和小鼠转录组数据集，我们鉴定了小富含亮氨酸蛋白 1 ( SMLR1 )，其编码小富含亮氨酸蛋白 1，这是一种功能未知的蛋白质，仅在肝脏和小肠中表达。