Gold nanoparticles display unique physicochemical features, which can be useful for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are slowly but steadily transitioning into clinical trials. Although initially thought to be “magic golden bullets” that could be used to treat a wide range of diseases, current consensus has moved toward a more realistic approach, where gold nanoformulations are being investigated to treat specific disorders. These therapeutic applications are dictated by the pharmacokinetics and biodistribution profiles of gold nanoparticles. Here, we analyze the current clinical landscape of therapeutic gold nanoconstructs, discuss the shared characteristics that allowed for their transition from bench to bedside, and examine existing hurdles that need to be overcome before they can be approved for clinical use.

Graphical Abstract

中文翻译：

---

纳米金的临床转化

金纳米粒子显示出独特的物理化学特性，可用于治疗目的。经过二十年的临床前进展，金纳米结构正在缓慢但稳步地过渡到临床试验。尽管最初被认为是可用于治疗多种疾病的“神奇金弹”，但目前的共识已转向更现实的方法，即研究金纳米制剂以治疗特定疾病。这些治疗应用取决于金纳米粒子的药代动力学和生物分布特征。在这里，我们分析了治疗性金纳米结构的当前临床前景，讨论了允许它们从工作台过渡到床边的共同特征，

图形概要