Systemic lupus erythematosus (SLE) is a disease that can lead to damage of multiple organs and, along with certain treatments, increase the risk of developing cancer, cardiovascular disease, diabetes, osteoporosis, and infections. Preventive services are particularly important in patients with SLE to mitigate the aforementioned risks. We aimed to evaluate the trends of preventive services utilization in patients with systemic lupus erythematosus, compared with non-SLE population. All ≥19-year-old patients in the Lupus Midwest Network (LUMEN) registry, a population-based cohort, with SLE on January 1, 2015, were included and matched (1:1) by sex, age, race, and county to non-SLE comparators. Among both groups, we compared the rates of screenings for breast and cervical cancer, hypertension, hyperlipidemia, diabetes mellitus, and osteoporosis as well as immunizations. We included 440 SLE patients and 430 non-SLE comparators. The probability of breast cancer screening among women with SLE was similar to comparators (hazard ratio [HR] 1.09, 95% CI 0.85–1.39), while cervical cancer screening was lower (HR 0.75, 95% CI 0.58–0.96). Hypertension screening was higher among patients with SLE (HR 1.35, 95% CI 1.13–1.62); however, hyperlipidemia screening was similar to comparators (HR 1.16, 95% CI 0.96–1.41). Diabetes and osteoporosis screenings were more likely to be performed for SLE patients than for comparators (HR 2.46, 95% CI 2.11–2.87; and HR 3.19, 95% CI 2.31–4.41; respectively). Influenza and pneumococcal immunizations were higher among SLE patients (HR 1.31, 95% CI 1.12–1.54; and HR 2.06, 95% CI 1.38–3.09; respectively), while zoster vaccination was similar (HR 1.17, 95% CI 0.81–1.69). The trends of utilization of preventive services by SLE patients vary according to screening or vaccine compared with the general population. Considering these differences, we demonstrate an opportunity for improvement, particularly in cervical cancer, hyperlipidemia, and osteoporosis screenings and vaccinations.

中文翻译：

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在系统性红斑狼疮人群队列中利用预防服务：中西部狼疮网络 (LUMEN) 研究

系统性红斑狼疮 (SLE) 是一种可导致多个器官损伤的疾病，配合某些治疗，会增加患癌症、心血管疾病、糖尿病、骨质疏松症和感染的风险。预防服务对于 SLE 患者尤其重要，以减轻上述风险。我们的目的是评估系统性红斑狼疮患者与非 SLE 人群相比预防服务利用的趋势。狼疮中西部网络 (LUMEN) 登记处（一个基于人群的队列）中所有 ≥19 岁的患者均被纳入，并按性别、年龄、种族和县进行匹配 (1:1)。与非 SLE 比较器。在两组中，我们比较了乳腺癌和宫颈癌、高血压、高脂血症、糖尿病、骨质疏松症的筛查率以及免疫接种率。我们纳入了 440 名 SLE 患者和 430 名非 SLE 对照者。患有 SLE 的女性进行乳腺癌筛查的概率与对照组相似（风险比 [HR] 1.09，95% CI 0.85–1.39），而宫颈癌筛查的概率较低（HR 0.75，95% CI 0.58–0.96）。SLE 患者的高血压筛查率较高（HR 1.35，95% CI 1.13–1.62）；然而，高脂血症筛查与对照组相似（HR 1.16，95% CI 0.96-1.41）。与对照组相比，SLE 患者更有可能进行糖尿病和骨质疏松症筛查（HR 2.46，95% CI 2.11–2.87；HR 3.19，95% CI 2.31–4.41）。SLE 患者的流感和肺炎球菌免疫接种率较高（分别为 HR 1.31，95% CI 1.12–1.54；HR 2.06，95% CI 1.38–3.09），而带状疱疹疫苗接种率相似（HR 1.17，95% CI 0.81–1.69） 。与一般人群相比，SLE 患者利用预防服务的趋势根据筛查或疫苗的不同而有所不同。考虑到这些差异，我们证明了改进的机会，特别是在宫颈癌、高脂血症和骨质疏松症筛查和疫苗接种方面。