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How I Approach Leishmaniasis: Diagnosis and Treatment in the United States.
Journal of the Pediatric Infectious Diseases Society ( IF 3.2 ) Pub Date : 2022-12-05 , DOI: 10.1093/jpids/piac087
Tara E Ness 1 , Rachel Martin-Blais 2, 3 , Jill E Weatherhead 1, 4, 5
Affiliation  

Leishmaniasis is a vector-borne disease caused by over 20 species of obligate intracellular protozoa belonging to the genus Leishmania. Leishmaniasis has a global distribution, including in the United States, and can cause a spectrum of clinical syndromes, including cutaneous, mucosal, and visceral diseases depending on host factors and the infecting Leishmania spp. Accurate diagnosis, including Leishmania species identification, is an important step to guide the most appropriate therapeutic intervention. Antileishmanial therapy is dependent on the Leishmania spp. identified, the clinical syndrome, and the child's immune system. However, many treatment regimens for children have been extrapolated from adult clinical trials, which may lead to underdosing and subsequent poor outcomes in infected children. Additional research is urgently needed to help guide therapy for children and determine appropriate antileishmanial agents, doses, and treatment courses for children with leishmaniasis.

中文翻译:

我如何处理利什曼病:在美国的诊断和治疗。

利什曼病是一种媒介传播的疾病,由属于利什曼原虫属的 20 多种专性细胞内原生动物引起。利什曼病在全球范围内分布,包括在美国,并可引起一系列临床综合征,包括皮肤、粘膜和内脏疾病,具体取决于宿主因素和感染的利什曼原虫属。准确的诊断,包括利什曼原虫物种鉴定,是指导最合适的治疗干预的重要一步。抗利什曼病治疗依赖于利什曼原虫属。确定、临床综合征和孩子的免疫系统。然而,许多儿童治疗方案是从成人临床试验中推断出来的,这可能会导致受感染儿童剂量不足以及随后的不良结果。迫切需要更多的研究来帮助指导儿童治疗,并确定适合利什曼病儿童的抗利什曼药物、剂量和治疗疗程。
更新日期:2022-08-31
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