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Effect of reduction in brain amyloid levels on change in cognitive and functional decline in randomized clinical trials: An instrumental variable meta-analysis
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-08-31 , DOI: 10.1002/alz.12768
Menglan Pang 1, 2 , Ling Zhu 1, 2 , Audrey Gabelle 1, 2 , Arie R Gafson 1, 2 , Robert W Platt 3 , James E Galvin 4 , Pierre Krolak-Salmon 5, 6 , Ivana Rubino 2 , Carl de Moor 1, 2 , Shibeshih Belachew 1, 2 , Changyu Shen 1, 2
Affiliation  

Whether the reduction in brain amyloid beta (Aβ) plaque alone may substantially slow cognitive and functional decline in patients with dementia or mild cognitive impairment due to Alzheimer's disease (AD) remains debated.

中文翻译:

随机临床试验中脑淀粉样蛋白水平降低对认知和功能下降变化的影响:工具变量荟萃分析

仅减少大脑β淀粉样蛋白(Aβ)斑块是否可以显着减缓痴呆或阿尔茨海默病(AD)引起的轻度认知障碍患者的认知和功能下降仍然存在争议。
更新日期:2022-08-31
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