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Oxygen-Generated Hierarchical-Structured AuNRs@MnO2@SiO2 Nanocarrier for Enhanced NIR- and H2O2-Responsive Mild-Hyperthermia Photodynamic/Photothermal Combined Tumor Therapy
Advanced Therapeutics ( IF 4.6 ) Pub Date : 2022-08-30 , DOI: 10.1002/adtp.202200108
Wen‐Jie Zheng 1 , Ze‐Lei Zhou 1 , Qi‐Yan Lv 1 , Xiaojie Song 1 , Wen‐Xing Zhang 1 , Hui‐Fang Cui 1
Affiliation  

Tumor hypoxia greatly restricts photodynamic therapy (PDT) efficiency. Photothermal therapy (PTT) implemented at high temperatures induces local skin burning and surrounding tissue damage. Herein, an near-infrared (NIR)- and H2O2-double responsive heat- and O2-generating core–shell–shell AuNRs@MnO2@SiO2 nanocarrier with Au nanorods (AuNRs) as core and MnO2 as sandwiched nanolayer is developed to realize enhanced photodynamic/photothermal combined tumor therapy at mild-hyperthermia temperatures. Coating poly-l-lysine on AuNRs is capable of preventing AuNRs from aggregation and facilitating the on-site growth of MnO2. The mesoporous SiO2 nanoshell provides large loading sites for payload indocyanine green (ICG). The MnO2 nanolayer greatly enhances the singlet oxygen (1O2) generation efficiency of ICG both in testing tubes and in cancer cells. Consequently, the O2-enhanced PDT endows the AuNRs@MnO2@SiO2-ICG nanoparticles (NPs) dramatically stronger antitumor effect both in vitro and in vivo. Their tumor growth inhibition ratio (67.6%) is significantly higher than that of AuNRs@SiO2-ICG (28.5%) after one dose intratumor injection and NIR irradiation. Together with their good biosafety, the AuNRs@MnO2@SiO2-ICG is promisingly translational. The multifunctionality should provide the AuNRs@MnO2@SiO2 NPs a nanocarrier platform for various therapeutic agents to modulate the tumor microenvironment and enhance tumor therapy efficiency.

中文翻译:

用于增强 NIR 和 H2O2 响应的轻度热疗光动力/光热联合肿瘤治疗的氧生成分级结构 AuNRs@MnO2@SiO2 纳米载体

肿瘤缺氧极大地限制了光动力疗法 (PDT) 的效率。在高温下实施的光热疗法 (PTT) 会引起局部皮肤灼伤和周围组织损伤。在此,近红外(NIR)-和H 2 O 2 -双响应热和O 2 -产生核-壳-壳AuNRs@MnO 2 @SiO 2纳米载体,以Au纳米棒(AuNRs)为核,MnO 2为夹心纳米层的开发是为了在温和的热疗温度下实现增强的光动力/光热联合肿瘤治疗。在AuNRs上包覆聚-l-赖氨酸能够防止AuNRs聚集并促进MnO 2的原位生长. 介孔 SiO 2纳米壳为有效载荷吲哚菁绿 (ICG) 提供了大的负载位点。MnO 2纳米层极大地提高了ICG在试管和癌细胞中的单线态氧( 1 O 2 )生成效率。因此,O 2增强的PDT赋予AuNRs@MnO 2 @SiO 2 -ICG纳米粒子(NPs)显着更强的体外和体内抗肿瘤作用。它们的肿瘤生长抑制率(67.6%)显着高于AuNRs@SiO 2 -ICG(28.5%),经过一剂瘤内注射和近红外照射。连同它们良好的生物安全性,AuNRs@MnO 2 @SiO 2-ICG 有望实现转化。多功能性应为 AuNRs@MnO 2 @SiO 2 NPs 提供一个纳米载体平台,用于各种治疗剂调节肿瘤微环境并提高肿瘤治疗效率。
更新日期:2022-08-30
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