Time-of-Flight Intracranial MRA at 3 T versus 5 T versus 7 T: Visualization of Distal Small Cerebral Arteries,Radiology

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Time-of-Flight Intracranial MRA at 3 T versus 5 T versus 7 T: Visualization of Distal Small Cerebral Arteries
Radiology ( IF 19.7 ) Pub Date : 2022-08-30 , DOI: 10.1148/radiol.220114
Zhang Shi ₁ , Xueying Zhao ₁ , Shuo Zhu ₁ , Xiyin Miao ₁ , Yunfei Zhang ₁ , Shihong Han ₁ , Bei Wang ₁ , Boyu Zhang ₁ , Xiaodan Ye ₁ , Yongming Dai ₁ , Caizhong Chen ₁ , Shengxiang Rao ₁ , Jiang Lin ₁ , Mengsu Zeng ₁ , He Wang ₁

Affiliation

Background

Three-dimensional (3D) time-of-flight (TOF) MR angiography (MRA) at 7 T has been reported to have high image quality for visualizing small perforating vessels. However, B₁ inhomogeneity and more physiologic considerations limit its applications. Angiography at 5 T may provide another choice for intracranial vascular imaging.

Purpose

To evaluate the image quality and cerebrovascular visualization of 5-T 3D TOF MRA for visualizing intracranial small branch arteries.

Materials and Methods

Participants (healthy volunteers or participants with a history of ischemic stroke undergoing intracranial CT angiography or MRA for identifying steno-occlusive disease) were prospectively included from September 2021 to November 2021. Each participant underwent 3-T, 5-T, and 7-T 3D TOF MRA with use of customized MR protocols within 48 hours. Radiologist scoring from 0 (invisible) to 3 (excellent) and quantitative assessment were obtained to evaluate the image quality. The Friedman test was used for comparison of characteristics derived from 3 T, 5 T, and 7 T.

Results

A total of 12 participants (mean age ± SD, 38 years ± 9; nine men) were included. Visualizations of the distal arteries and small vessels at 5-T TOF MRA were significantly higher than those at 3 T (median score: 3.0 vs 2.0, all P < .001 for distal segments and lenticulostriate artery; median score: 2.0 vs 0, P < .001 for pontine artery). The total length of small vessel branches detected at 5 T was larger than that at 3 T (5.1 m ± 0.7 vs 1.9 m ± 0.4; P < .001). However, there was no evidence of a significant difference compared with 7 T in either the depiction of distal segments and small vessel branches (average median score, 2.5; all P > .05) or the quantitative measurements (total length, 5.6 m ± 0.5; P = .41).

Conclusion

Three-dimensional time-of-flight MR angiography at 5 T presented the capability to provide superior visualization of distal large arteries and small vessel branches (in terms of subjective and quantitative assessment) to 3 T and had image quality similar to 7 T.

Online supplemental material is available for this article.

An earlier incorrect version appeared online. This article was corrected on September 14, 2022.

中文翻译：

3 T 与 5 T 与 7 T 的飞行时间颅内 MRA：远端小脑动脉的可视化

背景

据报道，7 T 的三维 (3D) 飞行时间 (TOF) MR 血管造影 (MRA) 具有较高的图像质量，可用于可视化小穿孔血管。然而，B _{1 的}不均匀性和更多的生理因素限制了它的应用。5 T 血管造影可能为颅内血管成像提供另一种选择。

目的

评估 5-T 3D TOF MRA 可视化颅内小分支动脉的图像质量和脑血管可视化。

材料和方法

2021 年 9 月至 2021 年 11 月前瞻性纳入了参与者（健康志愿者或有缺血性卒中病史并接受颅内 CT 血管造影或 MRA 以识别狭窄闭塞性疾病的参与者）。每位参与者均接受了 3-T、5-T 和 7-T 3D TOF MRA 在 48 小时内使用定制的 MR 协议。获得从 0（不可见）到 3（优秀）的放射科医生评分和定量评估以评估图像质量。Friedman 测试用于比较 3 T、5 T 和 7 T 的特性。

结果

总共包括 12 名参与者（平均年龄 ± SD，38 岁 ± 9；9 名男性）。5-T TOF MRA 的远端动脉和小血管的可视化显着高于 3 T（中位得分：3.0 对 2.0，远端段和豆纹动脉的所有P <.001；中位得分：2.0 对 0， P < .001 桥脑动脉）。在 5 T 时检测到的小血管分支总长度大于在 3 T 时检测到的小血管分支总长度（5.1 m ± 0.7 对 1.9 m ± 0.4；P < .001）。然而，与 7 T 相比，在远端节段和小血管分支的描绘（平均中位数得分，2.5；所有 P > .05）或定量测量（总长度，5.6 m ± 0.5）方面，没有证据表明存在显着差异; P=.41）。