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Kinetics and in vitro release studies of drug loaded silver nanoparticles from Indigofera tinctoria extract
Indian Journal of Chemical Technology ( IF 0.5 ) Pub Date : 2022-08-31
Yasmin Khambhaty, Suryakiran Bondada, Sujata Mandal

Silver nanoparticles (AgNP’s) have been successfully fabricated via bio-reduction of Indigofera tinctoria plant extract as the reducing and capping agent. The effects of pH and temperature on the formation of the AgNP’s have been studied. The synthesized AgNP’s have been characterized using UV-Visible spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, Zeta potential analysis, Scanning Electron Microscope (SEM) and Atomic Force Microscopy (AFM). Antimicrobial activities of the synthesized AgNP’s have been tested against both bacterial and fungal strains by agar well diffusion method. The biomass-capped AgNP’s imparted antimicrobial activity by inhibiting the growth of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Aspergillus niger and Penicillium chrysogenum. The antioxidant activities of the synthesized AgNP’s exhibit low IC50 value of ~55.72 μg/mL. Studies on drug loading and kinetics of drug release reveal that I. tinctoria AgNP’s follow the zero-order kinetics at pH 4.6 and pH 7.4. The gradient value of 0.568 (pH 4.6) and 0.6 (pH 7.4) falls between 0.42 < n < 0.85 when fitted into Peppa’s plot indicating that the drug release follow an anomalous transport or non-Fickian diffusion transport, indicating that the diffusion is time dependent.

中文翻译:

靛蓝提取物载药银纳米粒子的动力学和体外释放研究

银纳米粒子 (AgNP) 已通过生物还原靛蓝植物提取物作为还原剂和封端剂成功制备。已经研究了 pH 值和温度对 AgNP 形成的影响。已使用紫外-可见光谱、傅里叶变换红外 (FTIR) 光谱、Zeta 电位分析、扫描电子显微镜 (SEM) 和原子力显微镜 (AFM) 对合成的 AgNP 进行了表征。合成的 AgNP 的抗菌活性已通过琼脂井扩散法对细菌和真菌菌株进行了测试。生物质封端的 AgNP 通过抑制大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、蜡状芽孢杆菌、黑曲霉和产黄青霉的生长而赋予抗菌活性。合成的 AgNP 的抗氧化活性表现出较低的 IC50 值,约为 55.72 μg/mL。对药物负载和药物释放动力学的研究表明,I. tinctoria AgNP 在 pH 4.6 和 pH 7.4 下遵循零级动力学。当拟合到 Peppa 图中时,梯度值 0.568 (pH 4.6) 和 0.6 (pH 7.4) 介于 0.42 < n < 0.85 之间,表明药物释放遵循异常转运或非 Fickian 扩散转运,表明扩散与时间有关.
更新日期:2022-08-31
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