Abstract

Objective: We reviewed our experience with congenital hepatic hemangiomas (CHH) to assess the effectiveness of our treatment strategies. Methods: Clinical and pathologic features of children with CHH were reviewed. Results: Twenty-two cases of CHH were collected, 17 were resected and 5 were followed until resolution. In 17 with alpha-feto-protein (AFP) levels, 9 were elevated with 5 decreasing to normal before surgery. In six with tumors under 3 cm, five regressed between 1 and 13 months, one required removal 5 years after initial diagnosis. Postoperative histopathology of 17 cases showed abnormal vascular hyperplasia without lobular architecture. CD34 was expressed in all tumors, glucose transporter 1(Glut1) was negative. Conclusion: If the tumor is less than 3 cm, AFP is normal and there are no obvious complications, the lesion can be followed with regular assessment imaging. Surgical resection is an option in tumors less than 3 cm which have not regressed over time.

摘要

目的：我们回顾了我们治疗先天性肝血管瘤 (CHH) 的经验，以评估我们的治疗策略的有效性。方法：回顾儿童CHH的临床和病理特征。结果：共收集 22 例 CHH，切除 17 例，随访 5 例直至消退。在 17 名具有甲胎蛋白 (AFP) 水平的患者中，9 名升高，5 名在手术前降至正常。在 6 例肿瘤小于 3 cm 的患者中，5 例在 1 到 13 个月内消退，1 例在初步诊断后 5 年需要切除。17例术后组织病理示血管异常增生，无小叶结构。CD34在所有肿瘤中均有表达，葡萄糖转运蛋白1（Glut1）为阴性。结论：如果肿瘤小于3cm，AFP正常，无明显并发症，可定期影像学评估随访病灶。对于小于 3 cm 的肿瘤，随着时间的推移没有消退，手术切除是一种选择。