Control of the morphology and size of particles in processes like crystallization and precipitation remains challenging. We present the simple process of precipitation and controlled hydroxyapatite nanoparticles remodeling into the plate and rod-like morphologies. The precipitation/remodeling process assumes that the temperature and pH change of the remodeling step affect the properties of the resulting particles. The morphology and size of the nanoparticles were determined with scanning electron microscopy images. The functional groups were determined using Fourier Transform Infrared Spectroscopy, while the phase composition and crystallite size in x-ray diffraction experiments. Zeta potential measurements confirmed that particle morphology affects their stability in the aqueous suspensions. The results demonstrated the production of hydroxyapatite nanoparticles as aggregates of crystallites, in which particle morphology depends on remodeling temperature while their size on the remodeling time. Further, the process with lecithin added to modify particles' surfaces to enhance their biocompatibility maintains controllability over hydroxyapatite nanoparticles' morphologies.

中文翻译：

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板状和棒状羟基磷灰石纳米粒子的形态控制沉淀/重塑

在结晶和沉淀等过程中控制颗粒的形态和尺寸仍然具有挑战性。我们提出了简单的沉淀过程和可控的羟基磷灰石纳米粒子重塑为板状和棒状形态的过程。沉淀/重塑过程假定重塑步骤的温度和 pH 变化会影响所得颗粒的性质。用扫描电子显微镜图像确定纳米颗粒的形态和尺寸。使用傅里叶变换红外光谱确定官能团，而在 X 射线衍射实验中确定相组成和微晶尺寸。Zeta 电位测量证实颗粒形态会影响它们在水性悬浮液中的稳定性。结果表明羟基磷灰石纳米粒子的生产是作为微晶的聚集体，其中粒子形态取决于重塑温度，而它们的大小取决于重塑时间。此外，添加卵磷脂以修饰颗粒表面以增强其生物相容性的过程保持了对羟基磷灰石纳米颗粒形态的可控性。