Background and Purpose Pathological cardiomyocyte hypertrophy is a response to cardiac stress that typically leads to heart failure. Despite being a primary contributor to pathological cardiac remodeling, the therapeutic space that targets hypertrophy is limited. Here, we apply a network model to virtually screen for FDA-approved drugs that induce or suppress cardiomyocyte hypertrophy.

中文翻译：

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虚拟药物筛选揭示了心肌细胞肥大的上下文依赖性抑制

背景和目的病理性心肌细胞肥大是对心脏压力的反应，通常会导致心力衰竭。尽管是病理性心脏重塑的主要贡献者，但针对肥大的治疗空间是有限的。在这里，我们应用网络模型来虚拟筛选 FDA 批准的诱导或抑制心肌细胞肥大的药物。